• BioPharm.si - BioPharm.SI:Next Generation of Biologics
The Client : Ministrstvo za izobraževanje, znanost in šport ( BioPharm.si )
Project type: Projects Structural Funds
Project duration: 2016 - 2020
  • Description

Biologics are one the latest and perhaps the most

complex achievements of medicine. Biologics are

specific, with fewer side effects, enabling treatment

of previously incurable diseases. Slovenia

has achieved great successes in this field: the

first biosimilar approved in US was developed by

Slovenian company Lek and by National institute

of chemistry. Manufacturing of biologics is mainly

challenged by the complexity of the moleculesproteins

produced by genetically modified cells

in precisely controlled environments-bioreactors.

Yet small modifications of producing cell line,

production environment or conditions might impact

product quality and efficacy. In Bioinformatics

Laboratory we are collaborating with Lek and

other partners of BioPharm.SI to develop data

science infrastructure to monitor, store, organize

and mine the data from the production. Our aim

is to relate production parameters with quality

estimates and to optimize the production process.

To achieve this, Bioinformatics Laboratory

is adapting its data mining suite Orange, developing

data access components, and designing

new data visualization and mining tools to address

specific data types and observations and to

model the processes.