• SILICOFCM - In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy
The Client : Evropska komisija ( SILICOFCM )
Project type: European projects
Project duration: 2018 - 2021
  • Description

Cardiomyopathies are defined as abnormalities of the heart that are unexplained by the most frequent heart diagnoses. Familial cardiomyopathies (FCM) are most commonly diagnosed. Novel diagnoses and therapies need to be developed to affect the disease process and time course more fundamentally. Within the project, we will develop a cardiomyopathy risk stratification tool to mine heterogeneous patient data and thus provide an identification of high-risk patients (sudden cardiac death or life threating arrhythmias) that will be supplemented by prediction reliability estimates. We plan to adapt and evaluate the recently proposed algorithms for explanation of predictive models and predictions that shall provide efficient and reliable identification of disease patterns from large volumes of heterogeneous and noisy data.